Which cells secrete DKK1 and SFRPs in multiple myeloma to influence bone remodeling?

Which cells secrete DKK1 and SFRPs in multiple myeloma to influence bone remodeling?

• A. Myeloma cells
• B. Osteoblasts
• C. Osteoclasts
• D. Fibroblasts

Answer: (A)

In this context, the main idea is how myeloma cells disrupt bone formation. Malignant plasma cells in multiple myeloma secrete inhibitors of the Wnt signaling pathway, specifically DKK1 and secreted frizzled-related proteins (SFRPs). Wnt signaling promotes osteoblast differentiation and bone formation, so when DKK1 and SFRPs block this pathway, osteoblast activity decreases. That shift reduces new bone formation and contributes to the characteristic osteolytic lesions of multiple myeloma. So the cells responsible for releasing these inhibitors are the myeloma cells themselves, not the osteoblasts, osteoclasts, or fibroblasts.

In this context, the main idea is how myeloma cells disrupt bone formation. Malignant plasma cells in multiple myeloma secrete inhibitors of the Wnt signaling pathway, specifically DKK1 and secreted frizzled-related proteins (SFRPs). Wnt signaling promotes osteoblast differentiation and bone formation, so when DKK1 and SFRPs block this pathway, osteoblast activity decreases. That shift reduces new bone formation and contributes to the characteristic osteolytic lesions of multiple myeloma. So the cells responsible for releasing these inhibitors are the myeloma cells themselves, not the osteoblasts, osteoclasts, or fibroblasts.