What do osteoclasts arise from?

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Study for the Mandible, TMJ, and Bone Modeling Test. Delve into multiple choice questions, flashcards, and explanations, honing your expertise for success in the field!

Multiple Choice

What do osteoclasts arise from?

Explanation:
Osteoclasts come from the monocyte/macrophage lineage in the hematopoietic system. They form when monocyte-derived precursors fuse under signals such as M-CSF and RANKL, becoming multinucleated cells that resorb bone. This lineage distinction explains why osteoclasts are not from osteoblasts (bone-forming cells from mesenchymal stem cells), fibroblasts (mesenchymal-derived connective tissue cells), or chondrocytes (cartilage cells).

Osteoclasts come from the monocyte/macrophage lineage in the hematopoietic system. They form when monocyte-derived precursors fuse under signals such as M-CSF and RANKL, becoming multinucleated cells that resorb bone. This lineage distinction explains why osteoclasts are not from osteoblasts (bone-forming cells from mesenchymal stem cells), fibroblasts (mesenchymal-derived connective tissue cells), or chondrocytes (cartilage cells).

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